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Thrombelastography/thromboelastometry.

R J Luddington1

  • 1Haematology Department, Addenbrooke's Hospital, Cambridge, UK. roger.luddington@addenbrookes.nhs.uk

Clinical and Laboratory Haematology
|March 24, 2005
PubMed
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Thrombelastography (TEG) and rotational thromboelastometry (ROTEM) assess blood clotting. These viscoelastic measurements guide transfusions in surgery and are now used in pharmaceutical monitoring and patient screening.

Area of Science:

  • Coagulation science
  • Hemostasis analysis
  • Viscoelastic testing

Background:

  • Thrombelastography (TEG) measures viscoelastic changes during fibrin polymerization.
  • Rotational thromboelastometry (ROTEM) is a recent term for similar instrument output.
  • TEG/ROTEM technology has been used since 1948 for near-patient hemostasis assessment.

Purpose of the Study:

  • To provide a comprehensive overview of thrombelastography/thromboelastometry.
  • To highlight the historical development and evolving applications of the technology.
  • To discuss recent advancements in pharmaceutical monitoring and patient screening.

Main Methods:

  • Review of historical and recent literature on TEG/ROTEM.
  • Analysis of applications in clinical practice, particularly in surgery.

Related Experiment Videos

  • Examination of emerging uses in drug development and diagnostics.

    • Main Results:

    • TEG/ROTEM is crucial for near-patient hemostasis assessment.
    • Key applications include TEG-guided blood component transfusion in hepatic and cardiac surgery.
    • Renewed interest shows potential in pharmaceutical monitoring and patient screening.

    Conclusions:

    • Thrombelastography and rotational thromboelastometry are vital tools in hemostasis assessment.
    • The technology's utility extends from surgical transfusion guidance to modern pharmaceutical and screening applications.
    • Continued development promises broader clinical and research integration.