Related Experiment Video
Updated: Aug 18, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Enucleation and development of cluster headache: a retrospective study
Peter Sörös1, Oanh Vo, Heinrich Gerding
1Department of Neurology, Münster University Hospital, Albert-Schweizer-Strasse 33, 48149 Münster, Germany. soros@mac.com
Background:
Cluster headache (CH) is a neurovascular, primary headache disorder. There are, however, several case reports about patients whose CH started shortly after a structural brain disease or trauma. Motivated by a patient who developed CH 3 weeks after the removal of an eye and by similar case reports, we tested the hypothesis that the removal of an eye is a risk factor for CH.
Methods:
A detailed headache questionnaire was filled out by 112 patients on average 8 years after enucleation or evisceration of an eye.
Results:
While 21 % of these patients experienced previously unknown headaches after the removal of an eye, no patient fulfilled the diagnostic criteria for CH.
Conclusion:
Our data does not suggest that the removal of an eye is a major risk factor for the development of CH.
