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Related Experiment Videos

Methadone maintenance and male sexual dysfunction.

Randy Brown1, Stacey Balousek, Marlon Mundt

  • 1University of Wisconsin Medical Schoool, Department of Family Medicine, Madison, WI 53715, USA. Randy.Brown@fammed.wisc.edu

Journal of Addictive Diseases
|March 24, 2005
PubMed
Summary

Sexual dysfunction is common in men undergoing methadone maintenance therapy for opioid dependence. Orgasm dysfunction specifically correlates with methadone dosage and may improve with dose reduction.

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Area of Science:

  • Addiction Medicine
  • Sexual Health
  • Pharmacology

Background:

  • Opioid dependence is a chronic relapsing disease.
  • Methadone maintenance therapy (MMT) is a cornerstone of treatment.
  • Sexual dysfunction is a potential adverse effect of MMT.

Purpose of the Study:

  • To determine the prevalence and types of sexual dysfunction in men on MMT.
  • To identify factors associated with sexual dysfunction in this population.

Main Methods:

  • A cohort of 92 opioid-dependent men receiving MMT was studied.
  • Data were collected via questionnaires, research interviews, and laboratory measures.

Main Results:

  • Fourteen percent of men reported sexual dysfunction.

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  • Erectile dysfunction, libido dysfunction, and global dysfunction increased with age.
  • Higher methadone doses correlated with increased orgasm dysfunction.
  • Sexual dysfunction was not associated with testosterone or prolactin levels.

    • Conclusions:

    • The prevalence of global sexual dysfunction in men on MMT is comparable to the general population.
    • Orgasm dysfunction is a specific concern in MMT patients and may be linked to methadone dose.
    • Consider methadone dose reduction for managing orgasm dysfunction.