Effect of high calcium diet on cadmium-induced hypertension in rat

Effect of high calcium diet on the formation of hypertension induced by chronic cadmium chloride (CdCl2) treatment was investigated in Wistar rats. Intraperitoneal injection of CdCl2 solution (0.5 and 1.0 mg/kg/day) into female rats for two weeks resulted in an elevation of mean blood pressure. Bilateral adrenalectomy failed to prevent the CdCl2-induced hypertension. However, elevation of blood pressure from CdCl2 was not be found in rats on high calcium diet (4% Wt/Wt). Administration of high calcium diet influenced neither the blood pressure nor body weight of normal rats. My results suggest that high calcium diet may prevent the development of CdCl2-induced hypertension in rats.