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Related Experiment Videos

Psoriasiform eruption induced by propranolol.

S Halevy, E J Feuerman

    Cutis
    |July 1, 1979
    PubMed
    Summary

    A propranolol-induced psoriasiform eruption in a patient was identified. This drug reaction was confirmed by immune deposits, monoclonal gammopathy, and positive migration inhibiting factor test results.

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    Area of Science:

    • Dermatology
    • Immunology
    • Pharmacology

    Background:

    • Psoriasiform eruptions can be challenging to diagnose, sometimes mimicking psoriasis vulgaris.
    • Drug-induced skin reactions are a significant concern in patient management.
    • Beta-blockers like propranolol are commonly prescribed for various cardiovascular and neurological conditions.

    Observation:

    • A seventy-eight-year-old patient developed a psoriasiform eruption after one year of propranolol treatment.
    • Histopathology showed features similar to psoriasis vulgaris but was not definitively diagnostic.
    • The patient also experienced reduced tear secretion concurrently with the rash.

    Findings:

    • Immunologic investigations revealed immune deposits at the dermal-epidermal junction and in blood vessel walls.
    • Monoclonal gammopathy was detected in the patient.
    • A migration inhibiting factor test was positive for propranolol, and the eruption resolved after drug withdrawal.

    Implications:

    • This case suggests a potential drug reaction to propranolol presenting as a psoriasiform eruption.
    • The findings highlight the importance of considering drug-induced dermatoses in differential diagnoses.
    • Further research may elucidate the immunologic mechanisms underlying propranolol-associated skin reactions.

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