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Updated: Aug 18, 2026

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney
Published on: August 9, 2014
[Nephrogenic rests and nephroblastomatosis]
Elisabeth Perlman1, Frédérique Dijoud, Lilianne Boccon-Gibod
1Department of Pathology, Children's Memorial Hospital, Annex Bldg, Room A204, 2373 N. Lincold Avenue, Chicago, IL 60614, USA.
Abstract:
The term nephrogenic rests has been proposed for abnormally persistant foci of embryonal cells within developmentally normal kidneys. The term nephroblastomatosis is defined as the presence of diffuse or multiple nephrogenic rests. Nephrogenic rests represent precursors of nephroblatoma and they are associated with certain syndromes carrying a high risk for nephroblastoma. In his classification, Beckwith describes different types of nephrogenic rests according to topographic and morphological features. The nephrogenic rests may undergo regression or proliferation with a high risk for development of a nephroblatoma.
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