Related Experiment Video

Updated: Aug 18, 2026

Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment
06:05

Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment

Published on: June 2, 2023

[CD10 expression in a case of microvillous inclusion disease]

Nelly Youssef1, Frank M Ruemmele, Olivier Goulet

  • 1Service d'Anatomie Pathologique, France.

Annales De Pathologie
|March 24, 2005
PubMed

Insights

Microvillous inclusion disease is a rare congenital intestinal defect causing intractable diarrhea in infants. This case highlights combined bowel, colonic, and liver transplantation as a potential life-saving therapy for this severe condition.

Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Pathology
  • Surgical Gastroenterology

Background:

  • Microvillous inclusion disease (MID) is a rare congenital defect of the intestinal brush border.
  • Its etiology remains unknown, though autosomal recessive inheritance is suspected.
  • The disease presents with intractable diarrhea in infancy and has a very poor prognosis.

Observation:

  • This report details a case of microvillous atrophy, a form of MID.
  • The patient underwent a combined bowel, colonic, and liver transplantation.
  • Diagnostic tools for light microscopic identification are discussed.

Findings:

  • Combined organ transplantation was performed on a patient with microvillous atrophy.
  • The study discusses diagnostic methods for identifying this rare condition.
  • The prognosis for MID is extremely poor without intervention.

Implications:

  • Combined bowel-liver or bowel transplantation offers a potential life-saving treatment for MID.
  • Early diagnosis and intervention are crucial for managing this severe congenital disorder.
  • Further research into the etiology of MID may lead to novel therapeutic strategies.

More Related Videos

Automated Multiplex Immunofluorescence Panel for Immuno-oncology Studies on Formalin-fixed Carcinoma Tissue Specimens10:49

Automated Multiplex Immunofluorescence Panel for Immuno-oncology Studies on Formalin-fixed Carcinoma Tissue Specimens

Published on: January 21, 2019

Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells09:57

Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells

Published on: January 29, 2019

Related Concept Videos

Cell Inclusions01:27

Cell Inclusions

Prokaryotic cells possess a variety of inclusions that play crucial roles in nutrient storage, metabolic processes, and environmental adaptation. These structures enable bacteria to thrive under fluctuating environmental conditions by storing essential resources and optimizing their metabolic efficiency.Carbon Storage: Poly-β-Hydroxybutyric Acid and Glycogen GranulesBacteria frequently store excess carbon in specialized granules. Poly-β-hydroxybutyric acid (PHB) granules are lipid polymers that...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...