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Surgery for locally recurrent rectal cancer
Kirsten M Boyle1, Peter M Sagar, Alan G Chalmers
1Department of Surgery, The General Infirmary at Leeds, Leeds LS1 3EX, UK.
Diseases of the Colon and Rectum
|March 24, 2005
Summary
Surgical resection of locally recurrent rectal cancer is challenging but achievable. This study found that a significant number of patients with recurrent rectal cancer can achieve negative margins after surgery.
Area of Science:
- Oncology
- Surgical Oncology
- Gastrointestinal Surgery
Background:
- Locally recurrent rectal cancer after initial curative resection poses significant clinical and surgical challenges.
- Effective management strategies for locally recurrent rectal cancer are crucial for improving patient outcomes.
Purpose of the Study:
- To evaluate the outcomes of surgical resection for locally recurrent rectal cancer with curative intent.
- To assess the feasibility and success rates of resecting locally recurrent rectal cancer.
Main Methods:
- A retrospective review of 64 patients who underwent surgical exploration for locally recurrent rectal cancer between April 1997 and April 2004.
- Data collected included primary tumor details, surgical procedures, recurrence investigation, imaging, operative findings, and histopathology.
Main Results:
- Fifty-seven patients underwent tumor resection, with 36.8% achieving curative, negative resection margins.
- Wide resections were performed in 39 patients, while 18 required radical resection (pelvic exenteration or sacrectomy).
- Perioperative mortality was 1.6%, with significant postoperative morbidity in 40% of patients.
Conclusions:
- Resection of locally recurrent rectal cancer can achieve negative margins in a substantial proportion of patients.
- Surgical intervention for locally recurrent rectal cancer, despite its complexity, offers a potential for curative treatment.