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Resveratrol and breast cancer chemoprevention: molecular mechanisms

Ludovic Le Corre1, N Chalabi, L Delort

  • 1Laboratoire d'Oncologie Moléculaire, CBRV, Centre Jean Perrin, Clermont-Ferrand, France.

Molecular Nutrition & Food Research
|March 24, 2005
PubMed

Insights

Resveratrol (RES), a plant compound, shows promise in preventing breast cancer by acting against cancer initiation, promotion, and progression. Further research is needed to confirm its effectiveness as a chemopreventive agent.

Area of Science:

  • Oncology
  • Chemoprevention
  • Molecular Biology

Background:

  • Breast cancer remains a significant global health challenge for women.
  • Chemopreventive agents are emerging as a key strategy in combating cancer.
  • Resveratrol (RES), a plant-derived polyphenol, exhibits diverse biological activities, including anti-cancer properties.

Purpose of the Study:

  • To review the chemopreventive effects of Resveratrol (RES) across the three main stages of breast cancer development: initiation, promotion, and progression.
  • To summarize the molecular mechanisms underlying RES's potential in breast cancer prevention.

Main Methods:

  • Literature review of studies investigating Resveratrol's role in breast cancer.
  • Analysis of RES's effects on cellular processes relevant to carcinogenesis, including antioxidant and anti-inflammatory actions.
  • Examination of RES's impact on apoptosis, cell cycle regulation, and estrogen receptor function in breast cancer models.

Main Results:

  • Resveratrol demonstrates chemopreventive potential by inhibiting breast cancer initiation, promotion, and progression.
  • RES possesses antioxidant and anti-inflammatory properties beneficial in cancer prevention.
  • RES influences key cellular pathways, including inducing apoptosis, modulating the cell cycle, and affecting estrogen receptor activity in breast cancer cell lines.

Conclusions:

  • Resveratrol shows significant promise as a chemopreventive agent for breast cancer.
  • RES exhibits multifaceted biological activities that target critical stages of carcinogenesis.
  • Additional clinical studies are necessary to validate the therapeutic utility of RES in breast cancer prevention.

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