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Related Experiment Videos

[Age's influence in superficial bladder cancer's behaviour].

J L Moyano Calvo1, M Gutiérrez González, A Pérez-Lanzac Llorca

  • 1Servicio de Urología, Hospital Universitario Virgen Macarena de Sevilla, Fundación Joaquín Albarrán.

Actas Urologicas Espanolas
|March 25, 2005
PubMed
Summary

Transitional bladder cancer is less aggressive in young adults, with lower recurrence and no progression. Age is a key factor for recurrence, indicating a need for tailored treatment strategies.

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Area of Science:

  • Urology
  • Oncology
  • Pathology

Background:

  • Transitional bladder cancer (urothelial carcinoma) is uncommon in individuals under 41.
  • The clinical behavior and aggressiveness of bladder cancer in younger populations remain areas of active investigation.

Purpose of the Study:

  • To evaluate and compare the clinicopathological features and outcomes of transitional bladder cancer in patients younger than 41 years versus older patients.
  • To identify prognostic factors for tumor recurrence and progression in different age groups.

Main Methods:

  • Retrospective analysis of 551 primary bladder tumors with at least one year of follow-up.
  • Patients were divided into two groups: Group A (age < 41) and Group B (age > 40).
  • Comparison included tumor stage, grade, lymphatic permeation, multiplicity, recurrence, progression, sex, and time free of disease (T.L.E.), utilizing univariate and multivariate analyses.

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Main Results:

  • 17 tumors (2.1%) were identified in patients younger than 41.
  • Group A showed a significantly lower recurrence rate (11.8% vs. 36%, p=0.041) and no progression (0% vs. 4.1%, p=0.253) compared to Group B.
  • In Group A, lower recurrence was associated with T1 stage (13.3%), G2 grade (0%), absence of lymphatic permeation (0%), and solitary tumors (13.3%).

Conclusions:

  • Younger patients (<41 years) exhibit less pathological aggressiveness (0% G3) and a better recurrence-free survival.
  • Age group is an independent prognostic variable for recurrence, but not progression.
  • Despite a less aggressive behavior, younger patients have a higher incidence in women and specific tumor characteristics associated with lower recurrence.