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Disposable microfluidic devices: fabrication, function, and application.

Gina S Fiorini1, Daniel T Chiu

  • 1University of Washington, Seattle, WA 98195-1700, USA.

Biotechniques
|March 25, 2005
PubMed
Summary
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Recent advances in microfluidics focus on disposable plastic devices. This review covers fabrication methods, on-chip operations like fluid control and mixing, and biotechnological applications for this technology.

Area of Science:

  • Microfluidics
  • Polymer Science
  • Biotechnology

Background:

  • Microfluidics enables precise control of fluids in small-scale systems.
  • Disposable plastic devices offer cost-effective and accessible microfluidic solutions.

Purpose of the Study:

  • To review recent developments in microfluidics, particularly disposable plastic devices.
  • To provide an overview of fabrication techniques and on-chip operations.
  • To highlight biotechnological applications and future potential.

Main Methods:

  • Fabrication methods discussed include replica molding, injection molding, embossing, and laser ablation.
  • On-chip operations covered are fluid pumping, valving, reagent mixing, and separation/detection.
  • Biotechnological applications are presented through select case studies.

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Main Results:

  • Established methods for fabricating polymer microfluidic systems.
  • Demonstrated techniques for implementing essential on-chip operations.
  • Illustrated the versatility and potential of microfluidics in biotechnology.

Conclusions:

  • Disposable plastic microfluidics represent a significant area of advancement.
  • The technology offers diverse applications in biotechnology with future development potential.