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Bioactive benzophenones from Garcinia xanthochymus fruits
Scott Baggett1, Petr Protiva, Eugene P Mazzola
1Department of Biological Sciences, Lehman College and The Graduate School and University Center, The City University of New York, 250 Bedford Park Boulevard West, Bronx, New York 10468, USA.
Journal of Natural Products
|March 25, 2005
Summary
Two new benzophenones from Garcinia xanthochymus fruits, guttiferone H and gambogenone, show significant cytotoxicity against colon cancer cells. Both compounds also exhibit antioxidant activity, indicating potential therapeutic applications.
Area of Science:
- Natural Products Chemistry
- Pharmacology
- Medicinal Chemistry
Background:
- Garcinia xanthochymus fruits are a source of bioactive compounds.
- Benzophenones are a class of natural products with diverse biological activities.
Purpose of the Study:
- To isolate and characterize new benzophenones from Garcinia xanthochymus.
- To evaluate the cytotoxicity and antioxidant activity of isolated compounds.
Main Methods:
- Activity-guided fractionation of a methanol extract.
- Structure elucidation using 1D and 2D NMR spectroscopy.
- Cytotoxicity assays using SW-480 colon cancer cells.
- Antioxidant activity assessment using the DPPH assay.
Main Results:
- Two new benzophenones, guttiferone H (1) and gambogenone (2), were identified.
- Guttiferone H displayed cytotoxicity (IC50 = 12 microM) and antioxidant activity (IC50 = 64 microM).
- Gambogenone showed cytotoxicity (IC50 = 188 microM) and antioxidant activity (IC50 = 38.7 microM).
- Both compounds induced apoptosis in SW-480 cells.
Conclusions:
- Garcinia xanthochymus fruits yield novel benzophenones with promising anticancer and antioxidant properties.
- Guttiferone H and gambogenone represent potential leads for colon cancer therapeutics.
- Further investigation into the mechanism of action is warranted.