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Bisindigotin, a TCDD antagonist from the Chinese medicinal herb Isatis indigotica
Xiao Y Wei1, Chung Y Leung, Chris K C Wong
1Department of Biology, Hong Kong Baptist University, Kowloog Tong, Hong Kong, People's Republic of China.
Abstract:
A new indigoid derivative, bisindigotin (1), with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-antagonistic activity was isolated from the ethanol extract of the Chinese medicinal herb Isatis indigotica. Its structure was determined by spectroscopic methods. In the human HepG2 hepatoma cell model, 1 (50 nM to 2 microM) was found to dose-dependently inhibit TCDD-induced ethoxyresorufin O-deethylase (EROD) activity.