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Effect of maternal diabetes on phosphorylation of insulin-like growth factor binding protein-1 in cord serum

M Loukovaara1, P Leinonen, K Teramo

  • 1Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland. mikko.loukovaara@hus.fi

Diabetic Medicine : a Journal of the British Diabetic Association
|March 25, 2005
PubMed

Insights

Maternal diabetes in pregnancy is linked to lower levels of highly phosphorylated IGFBP-1 (hpIGFBP-1) in cord serum. This may increase insulin-like growth factor I (IGF-I) availability, potentially explaining fetal overgrowth (macrosomia) in diabetic pregnancies.

Area of Science:

  • Endocrinology
  • Reproductive Biology
  • Perinatal Medicine

Background:

  • The insulin-like growth factor (IGF) system regulates fetal growth.
  • Insulin-like growth factor binding proteins (IGFBPs) modulate IGF actions.
  • IGFBP-1 phosphorylation creates isoforms with differing IGF-I affinities.

Purpose of the Study:

  • To investigate cord serum IGFBP-1 phosphoisoform profiles in normal and diabetic pregnancies.
  • To correlate these profiles with fetal growth, particularly macrosomia in diabetic cases.

Main Methods:

  • Immunoenzymometric assays were used to measure cord serum IGFBP-1 phosphoisoforms.
  • Study included pregnancies with Type 1 diabetes, gestational diabetes, and normal pregnancies.

Main Results:

  • Cord serum highly phosphorylated IGFBP-1 (hpIGFBP-1) was significantly lower in diabetic pregnancies compared to controls.
  • Cord serum lesser phosphorylated IGFBP-1 (lpIGFBP-1) concentrations were similar across all groups.
  • Relative birth weight negatively correlated with hpIGFBP-1 and lpIGFBP-1 in diabetic pregnancies.

Conclusions:

  • Maternal diabetes is associated with suppressed hpIGFBP-1 but unaltered lpIGFBP-1 in fetal circulation.
  • Differential regulation of IGFBP-1 phosphoisoforms suggests altered IGF-I bioavailability in diabetic pregnancies.
  • This may contribute to the increased incidence of macrosomia observed in diabetic pregnancies.
Abstract

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