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[Relation between Helicobacter pylori and intractable gastric ulcer--PAS positive intramucosal mucus as an index]
K Sugiyama1, H Takahashi, R Fujita
1Department of Gastroenterology, Showa University Fujigaoka Hospital.
Abstract:
Helicobacter pylori (Hp) is considered to be one of the causes of gastric mucosal injury. Using biopsy specimens from the gastric mucosa of patients with gastritis or gastric ulcer, the intramucosal mucus was quantified by computer image analysis to evaluate its relationship with Hp. In gastric mucosa positive for Hp, the mucus content within the gastric mucosa was significantly decreased. Ammonia was administered based on its assumed role in decreasing the mucus content of the gastric mucosa, and resulted in a decrease in rats to whom it was administered. Based on these results, cases of intractable gastric ulcer were studied. In these intractable cases, Hp was present significantly more often than in other cases and the intramucosal mucus content was significantly lower. These findings suggest that Hp may be a factor in the resistance of gastric ulcer to treatment.
Insights
Helicobacter pylori (Hp) infection is linked to reduced stomach mucus, potentially hindering gastric ulcer healing. This suggests Hp may contribute to treatment resistance in gastric ulcers.
Area of Science:
- Gastroenterology
- Microbiology
- Pathology
Background:
- Helicobacter pylori (Hp) is implicated in gastric mucosal injury.
- Intramucosal mucus plays a crucial role in protecting the gastric lining.
Purpose of the Study:
- To investigate the relationship between Hp infection and intramucosal mucus content.
- To explore the potential role of Hp in the treatment resistance of gastric ulcers.
Main Methods:
- Quantification of intramucosal mucus using computer image analysis on gastric biopsy specimens.
- Administration of ammonia to rats to assess its effect on mucus content.
- Comparison of Hp prevalence and mucus levels in intractable gastric ulcers versus other cases.
Main Results:
- Gastric mucosa positive for Hp showed significantly decreased mucus content.
- Ammonia administration in rats led to a reduction in gastric mucus.
- Intractable gastric ulcers had a significantly higher prevalence of Hp and lower mucus content.
Conclusions:
- Hp infection may significantly reduce intramucosal mucus levels.
- Reduced mucus content associated with Hp infection could be a factor in gastric ulcer treatment resistance.