Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Screening for hepatocellular carcinoma.

S De Masi1, M E Tosti, A Mele

  • 1ASL, Livorno, Italy.

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
|March 25, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of the COVID-19 pandemic on the Italian national viral hepatitis surveillance: an interrupted time series analysis, 2006-2022.

Public health·2024
Same author

Short-Term Memory Deficit Associates with miR-153-3p Upregulation in the Hippocampus of Middle-Aged Mice.

Molecular neurobiology·2023
Same author

The Erice 58 Charter on 'The health of migrants. An equity challenge for the public health system'.

Annali di igiene : medicina preventiva e di comunita·2023
Same author

Daratumumab plus bortezomib or daratumumab plus lenalidomide as salvage therapy for patients with myeloma: initial follow-up of an Italian multicentre retrospective clinical experience by 'Rete Ematologica Pugliese'.

Annals of hematology·2022
Same author

Knowledge, attitude, barriers, professional behaviour and possible interventions: a survey on healthcare-associated infections among the healthcare workers of an intensive care unit in a large teaching hospital in Rome.

Annali di igiene : medicina preventiva e di comunita·2021
Same author

Renal Volume in ADPKD Patient Evaluation.

International journal of nephrology·2020
Same journal

Effectiveness and safety of mirikizumab in multirefractory ulcerative colitis: analysis from a real-world cohort.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2026
Same journal

Novel approaches to liquid biopsy in pancreatic cancer.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2026
Same journal

GLP-1 receptor agonists in pediatric obesity.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2026
Same journal

An unusual gastric mass in a patient with human immunodeficiency virus infection.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2026
Same journal

Fibrate therapy in primary sclerosing cholangitis: missing data on lipids, interactions, and cancer risk.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2026
Same journal

Pharmacovigilance of drug-induced microscopic colitis: time to consider exposure duration and dechallenge completeness.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2026
See all related articles

Hepatocellular carcinoma screening in cirrhotic patients is common but controversial. While screening may improve survival, its effectiveness and eligibility for treatment require further research and standardized protocols.

Area of Science:

  • Hepatology
  • Oncology
  • Diagnostic Imaging

Background:

  • High incidence of hepatocellular carcinoma (HCC) in cirrhotic patients (2-11%).
  • Current clinical practice widely employs periodic screening for HCC detection in cirrhosis.
  • Limited randomized trials exist, making effectiveness debated.

Purpose of the Study:

  • To review the scientific literature on hepatocellular carcinoma screening in cirrhotic patients.
  • To evaluate the effectiveness and controversies surrounding HCC screening protocols.

Main Methods:

  • Literature review of studies from MEDLINE and EMBASE (1990-2003).
  • Analysis of screening tests including alpha-fetoprotein and ultrasound.
  • Evaluation of study data on sensitivity, specificity, and survival outcomes.

Related Experiment Videos

Main Results:

  • Combined alpha-fetoprotein and ultrasound screening shows moderate sensitivity (50-85%) and specificity (70-90%).
  • Screening detects smaller, unifocal HCC, potentially improving outcomes for well-compensated cirrhosis.
  • Observational studies suggest longer survival for screening-detected HCC, but lead-time bias is a concern.

Conclusions:

  • The effectiveness of HCC screening in cirrhosis remains controversial despite common clinical use.
  • While some studies indicate survival benefits, eligibility for curative treatments like resection is often limited.
  • Standardization of screening schedules and evaluation of prevention programs are crucial.