Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bimanual recoupling by visual cueing in callosal disconnection.

Rüdiger J Seitz1, Raimund Kleiser, Cathrin M Bütefisch

  • 1Department of Neurology, University Hospital Düsseldorf, Düsseldorf, Germany. seitz@neurologie.uni-duesseldorf.de

Neurocase
|March 25, 2005
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Toward Free-Breathing Renal CEST MRI: Preclinical Evaluation of a Novel Prospective Respiratory Triggering Approach.

Magnetic resonance in medicine·2026
Same author

Toward Optimized Intravoxel Incoherent Motion (IVIM) and Compartmental T2 Mapping in Abdominal Organs.

Magnetic resonance in medicine·2026
Same author

Investigation of Endogenous Renal CEST Contrast and the Influence of Respiratory Motion on a Clinical 3 Tesla MRI: An In Vivo and In Vitro Study.

Magnetic resonance in medicine·2025
Same author

Evaluation of Partial Volume Correction Techniques for Sodium MRI of the Achilles Tendon.

Magnetic resonance in medicine·2025
Same author

Precision Through Detail: Radiomics and Windowing Techniques as Key for Detecting Dens Axis Fractures in CT Scans.

Diagnostics (Basel, Switzerland)·2025
Same author

Toward optimized intravoxel incoherent motion (IVIM) and compartmental T2 mapping in abdominal organs.

medRxiv : the preprint server for health sciences·2025

A corpus callosum lesion impaired bimanual coordination, causing uncoupled movements. Visual cues restored synchronized hand movements via a bihemispheric network.

Area of Science:

  • Neuroscience
  • Motor Control
  • Neurophysiology

Background:

  • Cerebral control of bimanual movements remains incompletely understood.
  • Bimanual coordination deficits can arise from disruptions in interhemispheric communication.
  • The role of the corpus callosum in coordinating complex motor tasks is a key area of research.

Observation:

  • A patient with an ischemic infarct of the entire corpus callosum presented with acute bimanual coordination deficits.
  • Transcranial magnetic stimulation revealed a lack of interhemispheric inhibition but normal intracortical inhibition.
  • Functional MRI showed uncoupled bimanual thumb-index oppositions during spontaneous movements.

Findings:

  • Spontaneous uncoupled bimanual movements were associated with activation of the left supplementary motor area, bilateral motor cortex, and anterior cerebellum.

Related Experiment Videos

  • Visually cued bimanual thumb-index oppositions became tightly correlated.
  • Synchronized movements engaged additional bilateral activations in the lateral occipital cortex, dorsal premotor cortex, and cerebellum.

    • Implications:

    • The corpus callosum is crucial for maintaining normal interhemispheric communication necessary for seamless bimanual coordination.
    • Visual cueing can re-establish coordinated bimanual movements by engaging a broader bihemispheric motor network.
    • This study highlights the brain's plasticity and network-level adaptations in response to focal white matter lesions affecting motor control.