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A Facile and Eco-friendly Route to Fabricate Poly(Lactic Acid) Scaffolds with Graded Pore Size
Published on: October 17, 2016
Porous poly (DL-lactic acid) modified chitosan-gelatin scaffolds for tissue engineering
Haifeng Liu1, Fanglian Yao, Yutao Zhou
1Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072, China.
Abstract:
Chitosan-gelatin (Cs-Gel) scaffolds are modified with poly (DL-lactic acid) (PDLLA) dichloromethane solution of different concentrations (0.1, 0.5, and 1.0%) and immersed in water after the evaporation of the solvent. The swollen scaffolds are freeze dried. The concentration of PDLLA has significant effects on both the physicomechanical properties and the cytocompatibility. Data reveal that only the 0.1% concentration could increase the tensile strength fourfold in comparison with the pristine Cs-Gel scaffold, while maintaining the human fibroblast adhesion, migration, and proliferation just like the Cs-Gel scaffold.
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