Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recent advances in 1,3-dipolar cycloaddition reactions on solid supports.

Kirsi Harju1, Jari Yli-Kauhaluoma

  • 1Viikki Drug Discovery Technology Center, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, FI-00014, Helsinki, Finland.

Molecular Diversity
|March 26, 2005
PubMed
Summary

Solid-phase synthesis offers efficient routes to diverse five-membered heterocycles using [3+2] cycloadditions. This review covers polymer-bound reactions and intramolecular cyclizations, expanding small molecule library construction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Drop-on-demand antimicrobial printed coatings loaded with a dehydroabietic acid derivative to prevent orthopedic implant infections.

Journal of materials chemistry. B·2026
Same author

Febuxostat analogs as anti-quorum sensing and antibacterial agents.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2025
Same author

Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases.

eLife·2025
Same author

Fluoroquinolones as versatile scaffolds: Potential for targeting classical and novel mechanisms to combat antibacterial resistance.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2025
Same author

Targeting bacterial and human levodopa decarboxylases for improved drug treatment of Parkinson's disease: Discovery and characterization of new inhibitors.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2025
Same author

The key phosphorus moieties in drug design: antimicrobials and beyond.

Future medicinal chemistry·2024

Area of Science:

  • Organic Synthesis
  • Medicinal Chemistry
  • Materials Science

Background:

  • Solid-phase synthesis is crucial for constructing molecular libraries.
  • Five-membered heterocycles are valuable building blocks in various applications.
  • 1,3-Dipolar cycloaddition reactions are key for heterocycle formation.

Purpose of the Study:

  • To review solid-phase synthesis of heterocycles via [3+2] cycloaddition.
  • To cover recent advancements in polymer-bound dipole and dipolarophile reactions.
  • To discuss intramolecular solid-phase cycloadditions.

Main Methods:

  • Utilizing polymer-bound dipoles and dipolarophiles.
  • Performing intramolecular solid-phase cycloadditions.
  • Describing reactions with various dipoles (azomethine ylides, nitrones, etc.) and dipolarophiles (alkenes, alkynes, imines).

Related Experiment Videos

Main Results:

  • Demonstrated versatility of solid-phase [3+2] cycloadditions for heterocycle synthesis.
  • Highlighted efficient construction of small organic molecule libraries.
  • Covered a wide range of dipole-dipolarophile combinations.

Conclusions:

  • Solid-phase [3+2] cycloaddition is a powerful strategy for diverse heterocycle synthesis.
  • This method facilitates rapid library generation for drug discovery and materials science.
  • The review provides a comprehensive overview of literature up to December 2003.