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Multiple antimicrobial resistant Salmonella enterica serovar Paratyphi B variant Java in cattle: a case report
S J Evans1, R H Davies, S H Binns
1Veterinary Laboratories Agency--Weybridge, Addlestone, Surrey KT15 3NB.
The Veterinary Record
|March 26, 2005
Summary
A Salmonella Paratyphi B variant Java strain resistant to multiple antibiotics was found in calves in Great Britain. This strain is genetically linked to human
Area of Science:
- Veterinary epidemiology
- Microbiology
- Antimicrobial resistance
Background:
- An investigation was initiated following the isolation of Salmonella enterica serovar Paratyphi B variant Java (S Java) from diseased calves.
- The identified S Java isolate exhibited resistance to a broad spectrum of antibiotics, including ampicillin, chloramphenicol, and tetracyclines.
Observation:
- The multi-drug resistant S Java was prevalent on the calf rearing unit and detected on an associated dairy premises, primarily in weaned calves.
- Extensive sampling across 10 linked farms did not yield further S Java isolates.
Findings:
- Molecular analysis revealed the S Java isolates were genetically similar to human strains linked to ornamental fish tanks and feed.
- A specific resistance island in the S Java isolates matched that found in human 'fish tank' strains and epidemic Salmonella Typhimurium DT104.
Implications:
- This is the first documented occurrence of S Java with this specific resistance profile in Great Britain.
- The genetic relatedness suggests a potential link between animal and human S Java strains, possibly through environmental or feed sources.
- Understanding the transmission dynamics of such resistant strains is crucial for public and animal health surveillance.