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Assessing Respiratory Immune Responses to Haemophilus Influenzae
Published on: June 29, 2021
Respiratory illness during winter: a cohort study of urban children from temperate Australia
S B Lambert1, K F O'Grady, S H Gabriel
1Murdoch Childrens Research Institute, Royal Children's Hospital, Australia. s.lambert@unimelb.edu.au <s.lambert@unimelb.edu.au>
Insights
Respiratory illnesses are common in Australian children, with influenza-like illness (ILI) episodes impacting young children and those in daycare. These illnesses lead to significant healthcare use and parental time burdens.
Area of Science:
- Pediatric respiratory health
- Epidemiology of infectious diseases
- Public health in Australia
Background:
- Winter respiratory illnesses pose a significant health burden on urban children.
- Understanding the epidemiology of these illnesses is crucial for effective public health interventions.
Purpose of the Study:
- To investigate the epidemiology and burden of winter respiratory illnesses in urban Australian children.
- To identify risk factors associated with influenza-like illness (ILI) in this population.
Main Methods:
- A cohort study involving healthy Melbourne children aged 12-71 months.
- Daily symptom diaries and resource use logs were maintained by parents during ILI episodes.
Main Results:
- 118 children experienced 137 ILI episodes over 12 weeks (0.53 episodes/child-month).
- Younger age, fewer household members, daycare attendance, and higher income were ILI risk factors.
- Episodes averaged 10.4 days, with high rates of general practitioner visits, antibiotic prescriptions, and hospitalizations, alongside significant parental time costs.
Conclusions:
- Respiratory illnesses represent a common yet underestimated cause of morbidity in Australian children.
- Further pathogen-specific data are needed to guide vaccine and treatment strategies.
Objective:
To examine the epidemiology and burden of respiratory illness during winter in urban children from temperate Australia.
Methods:
We conducted a cohort study of healthy Melbourne children, aged from 12 to 71 months. Parents kept a daily respiratory symptom diary and recorded resource use when an influenza-like illness (ILI) occurred.
Results:
One-hundred and eighteen children had 137 ILI episodes over 12 weeks for a rate of 0.53 ILI episodes per child-month (95% CI 0.44-0.61). Risk factors for ILI included younger age, fewer people residing in the household, structured exposure to other children outside the home, and a higher household income. Episodes had a mean duration of 10.4 days with 64 visits to a general practitioner (46.7 GP visits per 100 episodes), 27 antibiotic courses prescribed (19.7 antibiotic courses per 100 episodes), and three overnight hospitalizations (2.2 admissions per 100 episodes). Parents reported an average of 11.7 h excess time spent caring for a child per episode.
Conclusions:
Respiratory illnesses are a common and largely neglected cause of illness in Australian children. Pathogen-specific data are required to better assess the likely impact of available and developing vaccines and other treatment options.
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