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CD36: a multiligand molecule

Yimin Ge1, M Tarek Elghetany

  • 1Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555, USA.

Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology
|March 26, 2005
PubMed

Insights

CD36 is a vital receptor implicated in numerous diseases like atherosclerosis and cancer. Understanding its diverse roles is key to developing new therapeutic strategies for these conditions.

Area of Science:

  • Molecular Biology
  • Immunology
  • Pathology

Background:

  • CD36 is a multiligand receptor involved in various physiological processes.
  • It is associated with diverse disorders including atherosclerosis, insulin resistance, diabetes, dyslipidemia, tumor angiogenesis, and Plasmodium falciparum infection.
  • CD36 deficiency is prevalent in certain ethnic groups, such as African Americans and Asians.

Purpose of the Study:

  • To review the multifaceted roles of CD36 in health and disease.
  • To highlight CD36's involvement in conditions ranging from metabolic disorders to cancer and infectious diseases.
  • To discuss the therapeutic potential of targeting CD36.

Main Methods:

  • Literature review and synthesis of existing research on CD36.
  • Analysis of CD36 expression patterns in various cell types and diseases.
  • Examination of CD36's function as a receptor for thrombospondin 1 and its role in angiogenesis.

Main Results:

  • CD36 is expressed on blasts in acute monocytic leukemia, megakaryoblastic leukemia, and erythroleukemia.
  • Its role in sickle cell crises and cerebral malaria is still under investigation.
  • CD36's function in regulating angiogenesis presents a potential therapeutic target for malignant neoplasms.

Conclusions:

  • CD36 is a critical receptor with diverse functions and implications in numerous diseases.
  • Further research into CD36's mechanisms is essential for developing effective disease interventions.
  • Targeting CD36 offers a promising avenue for therapeutic strategies against various pathologies.

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