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Acute hemorrhagic leukoencephalitis (Hurst's disease) linked to Epstein-Barr virus infection

Markus Hofer1, Achim Weber, Karsten Haffner

  • 1Department of Neuropathology, Institute for Pathology, University Hospital Freiburg, Breisacherstr. 64, 79106, Freiburg, Germany, hofer@nz.ukl.uni-freiburg.de.

Acta Neuropathologica
|March 26, 2005
PubMed

A 16-year-old girl presented signs of a common cold in combination with a hemolytic crisis. Within 3 days, she developed reduced consciousness and hemiparesis subsequently followed by coma. CT and MRI scans revealed evidence for raised intracranial pressure and an extensive inflammatory process extending from the brain stem up to the thalamus. The patient died within 3 weeks after onset of first symptoms of intracranial pressure despite maximum intensive care. Neuropathological examination revealed disseminated necrotic lesions and perivascular hemorrhages characteristic for acute hemorrhagic leukoencephalitis (Hurst's disease), mainly of the brain stem, diencephalon and cerebellum. Serological results, in situ hybridization and PCR analysis demonstrated an acute Epstein-Barr virus (EBV) infection of the central nervous system. To our knowledge, this is the first reported case of Hurst's disease linked to EBV.

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