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Parallel reactor systems for bioprocess development.

Dirk Weuster-Botz1

  • 1Lehrstuhl für Bioverfahrenstechnik, Technische Universität München, Boltzmannstrasse 15, 85748 Garching, Germany. d.weuster-botz@lrz.tum.de

Advances in Biochemical Engineering/Biotechnology
|March 29, 2005
PubMed
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Controlled parallel bioreactor systems enable efficient early-stage fed-batch process development. This approach enhances bioprocess development through parallel operation and advanced control strategies.

Area of Science:

  • Biotechnology
  • Biochemical Engineering

Background:

  • Controlled parallel bioreactor systems facilitate fed-batch operations during early bioprocess development.
  • Various bioreactor types, including shaken, sparged, and stirred systems, are evaluated for parallel operation.

Purpose of the Study:

  • To summarize the characteristics of different parallel bioreactor systems.
  • To demonstrate the effectiveness of controlled parallel reactor systems in bioprocess development.

Main Methods:

  • Summarized characteristics of shaken, sparged, and stirred bioreactors for parallel operation.
  • Implemented an intermittent feeding and pH-control system for up to 16 parallel bioreactors (100 ml scale).
  • Demonstrated scale-up and scale-down of pH-controlled microbial fed-batch processes.

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Main Results:

  • Parallel fed-batch operation was successfully achieved using the developed system.
  • Controlled parallel reactor systems proved effective for bioprocess development.
  • Scale-up and scale-down examples validated the system's utility.

Conclusions:

  • Controlled parallel bioreactor systems offer a more effective approach to bioprocess development.
  • Future developments include larger parallel systems with advanced controls (pH, pO2) and automation.
  • The technology enables efficient optimization of microbial fed-batch processes at the milliliter scale.