Protein expression pattern of CDK11(p58) during testicular development in the mouse

Ziyue Niu1, Aiguo Shen, Hailian Shen

  • 1State Key Laboratory of Genetic Engineering & Gene Research Center, Shanghai Medical College of Fudan University, Shanghai, People's Republic of China.

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Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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