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Frequency distribution of dextromethorphan O-demethylation in a Greek population
V K Kimiskidis1, I Niopas, P D Firinidis
1Department of Neurology, George Papanicolaou Hospital, Aristotle University, Thessaloniki, Greece.
Objective:
To determine the CYP2D6 phenotype in a Greek population by using dextromethorphan (DM) as a probe drug.
Methods:
DM (30 mg) was given orally to 102 unrelated Greek subjects and 8-hour urine samples were collected. Concentrations of DM and its metabolite dextrorphan (DX) were determined using a validated HPLC assay. Metabolic molar ratio (MR) of DM to free DX in log form was used as an in vivo index of metabolic status.
Results:
The frequency distribution histogram of MR was bimodal. An antimode of 0.25 for the mean log MR was determined using probit analysis. Seven of 102 subjects (6.9%) were poor metabolizers (PMs).
Conclusion:
The PM frequency of CYP2D6 in Greek subjects was similar to other Caucasian populations.
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