Related Experiment Video
Updated: Aug 18, 2026

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
Published on: December 13, 2017
Treatment of phenylketonuria-associated tremor with deep brain stimulation: case report
Mary Say Payne1, Benjamin Lyons Brown, Jayaraman Rao
1Department of Neurology, Louisiana State University Medical School, New Orleans, Louisiana 70112, USA. bpayne1@lsuhsc.edu
Objective And Importance:
Phenylketonuria (PKU) is an inborn error of metabolism that causes severe neurological impairment, despite dietary treatment. We present a case of PKU-induced cerebellar tremor treated with deep brain stimulation. There have been no previously reported cases of a patient with a PKU tremor treated with deep brain stimulation.
Clinical Presentation:
A 36-year-old male patient with PKU presented with signs of cerebellar disease including dysmetria, resting tremor, and intention tremor in the left upper extremity.
Intervention:
A deep brain stimulation electrode was placed in the ventral intermediate nucleus of the right thalamus.
Conclusion:
Immediately after surgery, the patient had nearly complete resolution of intention tremor in the left arm. His resting tremor in the left hand was also greatly improved. The 30-month follow-up examination revealed maintenance of the immediate postoperative improvement.
More Related Videos
Related Concept Videos
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Electroconvulsive Therapy
Alterations in Muscle Tone lll

