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Cloning, characterization, and expression analysis of hepcidin gene from red sea bream (Chrysophrys major)
Song-Lin Chen1, Mei-Yu Xu, Xiang-Shan Ji
1Yellow Sea Fisheries Research Institute, Chinese Academy of Fisheries Sciences, Nanjing Road 106, 266071 Qingdao, People's Republic of China. chensl@ysfri.ac.cn
Antimicrobial Agents and Chemotherapy
|March 29, 2005
Abstract:
A cDNA encoding hepcidin was isolated from a library of cDNA from spleen of red sea bream (Chrysophrys major) by expressed sequence tag analysis. The expression of the hepcidin mRNA in various tissues was examined. Challenge of red sea bream with Escherichia coli DH5alpha elevated hepcidin mRNA levels in spleen, gill, liver, and intestine.
