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Updated: Aug 18, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
TGF-beta1 polymorphism determines the progression of joint damage in rheumatoid arthritis
1Department of Orthopaedic Surgery, Kyungpook National University School of Medicine, Daegu, South Korea.
Objective:
To determine whether transforming growth factor-beta1 (TGF-beta1) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA) and to analyse whether they can affect the progression of radiographic severity.
Methods:
A total of 143 RA patients and 148 healthy unrelated controls were tested for the TGF-beta1 polymorphisms using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).
Results:
The TGF-beta1 polymorphisms were not associated with susceptibility to RA, although there was a trend that -509C/T and the 869T/C polymorphisms were associated with RA in the male population. The progression of radiographic severity, which was defined by a modified Sharp score plotted against disease duration, was significantly faster in the carrier of T allele at the -509 (p=0.048).
Conclusion:
Our data support the hypothesis that TGF-beta1 polymorphism may determine the progression of joint destruction in RA.
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