Urothelial changes induced by therapeutic procedures for bladder cancer. A review
Roberta Mazzucchelli1, Francesca Barbisan, Lucia M Tarquini
1Section of Pathologic Anatomy and Histopathology and Institute of Urology, School of Medicine, Polytechnic University of the Marche Region, Ancona, Italy. rmaz@libero.it
Abstract:
Topical and systemic therapeutic agents and treatment modalities, such as thiotepa and mitomycin C, cyclophosphamide, bacillus Calmette-Guerin, radiation therapy, photodynamic and laser therapy, and gene therapy, produce a host of changes in the bladder, some of them mimicking cancer. Pathologists must be aware that following these types of treatment, the clinical utility of urinary cytology is reduced.
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