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Updated: Aug 18, 2026

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Toxicity of the topoisomerase II inhibitors
1New York Medical College, Room 250 Munger Pavilion, Valhalla, New York 10595, USA. Karen_Seiter@nymc.edu
Abstract:
Topoisomerase II inhibitors represent a broad class of antineoplastic agents with a wide spectrum of activity against malignancies. Topoisomerase II inhibitors include the anthracyclines, mitoxantrone and epipodophyllotoxins. Short-term toxicity includes myelosuppression and gastrointestinal toxicity. Long-term survivors are at risk of cardiac toxicity and secondary leukaemia. This article discusses these toxicities in detail, including administration of these agents to patients with hepatic and/or renal insufficiency, and the need for dose adjustments in selected patient populations.
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