Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

5-fluorouracil as a phosensitiser.

Mihail Lucian Pascu1, Mihail Brezeanu, Letitia Voicu

  • 1National Institute for Lasers, Plasma and Radiation Physics, Laser Department, Bucharest - Magurele. mpascu@cost.esf.org

In Vivo (Athens, Greece)
|March 31, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Photothermal-Responsive Polyvinyl Alcohol/Gelatin/Graphene Oxide Hydrogels Loaded with Quercetin for NIR-Triggered Controlled Drug Delivery.

Gels (Basel, Switzerland)·2026
Same author

Spectroscopic Analysis of the TiO<sub>2</sub> Nanoparticles Influence on the Interaction of 5,10,15,20-(Tetra-4-carboxyphenyl)porphyrin with Human Serum Albumin.

International journal of molecular sciences·2026
Same author

Correction: Balas et al. Photodynamic Activity of TMPyP4/TiO<sub>2</sub> Complex under Blue Light in Human Melanoma Cells: Potential for Cancer-Selective Therapy. <i>Pharmaceutics</i> 2023, <i>15</i>, 1194.

Pharmaceutics·2025
Same author

Laser-Induced Dimeric Photoproducts of Chlorpromazine: LC-MS Identification and Molecular Docking Evidence of Enhanced Anticancer Potential.

International journal of molecular sciences·2025
Same author

Photodegradation of psychotropic medications: Impact on efficacy, safety, and drug properties.

Computers in biology and medicine·2025
Same author

Enhancement of chlorpromazine efficacy in breast cancer treatment by 266 nm laser irradiation.

Scientific reports·2024

5-Fluorouracil (5-FU) shows strong fluorescence when exposed to UV-vis light. This light exposure also significantly boosted the cancer-fighting effects of 5-FU in living organisms.

Area of Science:

  • Biochemistry
  • Photochemistry
  • Pharmacology

Background:

  • 5-Fluorouracil (5-FU) is a widely used chemotherapeutic agent.
  • The photophysical properties of 5-FU are not fully understood.
  • Investigating novel therapeutic strategies for cancer treatment is crucial.

Purpose of the Study:

  • To investigate the fluorescence properties of 5-FU upon UV-vis irradiation.
  • To evaluate the impact of UV-vis irradiation on the cytostatic activity of 5-FU in vivo.

Main Methods:

  • Irradiation of 5-FU with UV-vis light.
  • Measurement of 5-FU fluorescence.
  • Assessment of 5-FU cytostatic activity in an in vivo experimental model.

Main Results:

Related Experiment Videos

  • 5-FU demonstrated significant fluorescence when irradiated with UV-vis light.
  • UV-vis irradiation led to an enhanced cytostatic effect of 5-FU.
  • The observed enhancement was validated in a living organism model.

Conclusions:

  • UV-vis irradiation can modulate the photophysical and biological properties of 5-FU.
  • This finding suggests a potential for photodynamic enhancement of 5-FU chemotherapy.
  • Further research into light-activated chemotherapy warrants investigation.