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Related Experiment Video

Updated: Feb 9, 2026

Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma
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[Mandibular lesions in multiple myeloma].

P N Scutellari1, C Orzincolo

  • 1Istituto di Radiologia, Università degli Studi, Ferrara.

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|March 1, 1992
PubMed
Summary
This summary is machine-generated.

Multiple myeloma, a cancer of plasma cells, frequently affects the jawbone. This review found 10.54% of patients had mandibular involvement, often presenting as "punched-out" lesions on X-rays.

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Area of Science:

  • Hematology
  • Radiology
  • Oncology

Background:

  • Multiple myeloma is a plasma cell malignancy.
  • Skeletal involvement is common in multiple myeloma.
  • Oral and jaw manifestations are reported but may be underdiagnosed.

Purpose of the Study:

  • To determine the incidence of mandibular involvement in multiple myeloma.
  • To describe the clinical and radiographic features of jaw lesions in multiple myeloma.

Main Methods:

  • Retrospective review of 237 multiple myeloma cases.
  • Analysis of skeletal involvement, specifically the mandible.
  • Correlation of clinical symptoms and radiographic findings.

Main Results:

  • Mandibular skeletal involvement was identified in 25 patients (10.54%).
  • Common symptoms included oral pain, swelling, tooth loss, and lip paresthesia.
  • Radiographic findings typically showed "punched-out" lytic defects, occasionally "bubbly" or septated; rare cases presented as permeative lesions.

Conclusions:

  • Mandibular involvement is a significant, though potentially underestimated, manifestation of multiple myeloma.
  • Systematic radiographic evaluation of the jaws could reveal a higher incidence.
  • Early recognition of oral symptoms and radiographic changes is crucial for diagnosis and management.