Related Experiment Video
Updated: Aug 18, 2026
A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds
Published on: February 23, 2024
[Experimental study on early escharectomy after major burns in minipigs]
Gang Xu1, Chen-Wang Duan, Shu-Qiang Chen
1Burn Institute, The Worker's Hospital of Tangshan, The Hebei Medical University, Tangshan 063000, P.R. China.
Objective:
To investigate optimal time for early escharectomy after severe scald in minipigs.
Methods:
Minipigs inflicted with 35% TBSA full thickness burn were employed in the study, and they were randomly divided into A (n = 7, with escharectomy at 6PSH), and B (n = 7, with escharectomy at 24 PSH) groups. The hemodynamics indices, hemorrheology, and the serum levels of cytokines in the two groups were determined before burns and at 6, 8, 16, 24 and 72PSH.
Results:
The hemodynamics indices in A group obviously improved compared with those in B group. The cardiac output (CO, 2.28 +/- 0.03 L/min) and right arterial pressure (RAP, 4.54 +/- 0.04 mmHg) in A group recovered to the pre-injury levels at 48 PSH. There was no difference of the hemorrheology indices between the two groups (P > 0.05). The serum contents of cytokines in A group declined to the pre-injury level on 1 PBW, while those in B group were significantly higher than those before injury and those in A group (P < 0.05 or P > 0.01).
Conclusion:
Escharectomy during 6 PBH might be safe and feasible, thus preventing long-term complications effectively.
