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Depression predicts mortality following cardiac valve surgery
P Michael Ho1, Frederick A Masoudi, John A Spertus
1Cardiology and Cardiovascular Outcomes Research, Denver VA Medical Center, Denver, Colorado, USA. michael.ho@uchsc.edu
The Annals of Thoracic Surgery
|March 31, 2005
Summary
Preoperative depression is a significant predictor of mortality in patients undergoing cardiac valve surgery. Identifying and treating depression may improve patient survival rates after this procedure.
Area of Science:
- Cardiology
- Psychiatry
- Health Services Research
Background:
- Depression is linked to mortality in cardiovascular disease.
- Its impact on outcomes after cardiac valve surgery is not well-established.
- Identifying non-surgical factors influencing survival is crucial for risk assessment and intervention.
Purpose of the Study:
- To investigate the hypothesis that depression predicts mortality in patients undergoing cardiac valve surgery.
- To assess the association between preoperative depression and 6-month all-cause mortality.
Main Methods:
- Prospective cohort study of 648 patients undergoing valve surgery.
- Preoperative Mental Health Inventory (MHI) depression screening.
- Multivariable logistic regression to analyze the association between depression and mortality, adjusting for clinical variables.
Main Results:
- 29.2% of patients were depressed preoperatively.
- Depression was significantly associated with increased 6-month all-cause mortality (OR 1.90, p=0.03).
- This association held across different valve surgery subgroups.
Conclusions:
- Preoperative depression is an independent risk factor for mortality post-cardiac valve surgery.
- Incorporate depression screening into preoperative risk stratification.
- Further research is needed to evaluate the efficacy of depression interventions in improving outcomes.