Related Experiment Video
Updated: Aug 18, 2026

Following Cell-fate in E. coli After Infection by Phage Lambda
Published on: October 14, 2011
Revisited gene regulation in bacteriophage lambda
Ian B Dodd1, Keith E Shearwin, J Barry Egan
1Discipline of Biochemistry, School of Molecular and Biomedical Science, University of Adelaide, South Australia 5005, Australia. ian.dodd@adelaide.edu.au
Abstract:
The contribution of bacteriophage lambda to gene control research is far from over. A revised model of the lambda genetic switch includes extra cooperativity through octamerization of the cI repressor protein, mediated by long-range DNA looping. Structural analysis reveals remarkably subtle transcriptional activation by cI. The action of cI, activation by cII, and aspects of antitermination by N and Q all confirm the utility and versatility of simple, weak adhesive interactions mediated by nucleic acid tethers. New genetic and quantitative analysis of the lambda gene network is challenging cherished ideas about how complex behaviours emerge from this regulatory system.
Related Concept Videos
Viral Replication: Lysogenic Cycle
Regulation of Bacterial Virulence
DNA Bacteriophages
Lysogenic Cycle of Bacteriophages
Prokaryotic Transcriptional Activators and Repressors
Transcription of prokaryotic...
Prokaryotic Transcriptional Activators and Repressors
Transcription of prokaryotic...

