Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Combinatorial Gene Control02:33

Combinatorial Gene Control

8.6K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
8.6K
Hierarchy of Motor Control01:18

Hierarchy of Motor Control

5.6K
The hierarchy of motor control refers to the different levels of organization and processing involved in controlling movement in the body. These levels range from higher cortical areas involved in planning and decision-making to lower spinal cord reflexes that respond automatically to external stimuli.
5.6K
Control Systems01:10

Control Systems

1.7K
Control systems are everywhere in contemporary society, influencing diverse applications from aerospace to automated manufacturing. These systems can be found naturally within biological processes, such as blood sugar regulation and heart rate adjustment in response to stress, as well as in man-made systems like elevators and automated vehicles. A control system is essentially a network of subsystems and processes that collaboratively convert specific inputs into desired outputs.
At the heart...
1.7K
Control Systems: Applications01:25

Control Systems: Applications

1.2K
Electrical engineering plays a pivotal role in our daily lives, with control systems at the heart of many applications, from home appliances to sophisticated space shuttles. Control systems manage and regulate the behavior of devices and processes, ensuring they function safely, correctly, and efficiently.
In modern vehicles, control systems manage various functions to enhance performance and safety. The steering wheel and accelerator are primary inputs in a car's control system. The...
1.2K
Rotter's Locus of Control01:14

Rotter's Locus of Control

1.4K
Julian Rotter introduced the concept of locus of control, a cognitive factor that significantly influences personality development and learning. Locus of control refers to an individual's beliefs about the extent of control they have over events in their lives. According to Rotter, this belief system can be categorized into two types: internal and external locus of control.
Individuals with an internal locus of control believe that their personal efforts and decisions directly affect their...
1.4K
Locus of Control01:26

Locus of Control

406
Locus of control describes how individuals perceive the causes of events in their lives, influencing motivation and well-being. Introduced by Julian Rotter in 1954, it is categorized into internal and external locus of control.Internal Locus of ControlIndividuals with an internal locus of control believe their actions determine outcomes, fostering responsibility, self-efficacy, and motivation. For example, an employee may attribute career success to hard work. Research links this mindset to...
406

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The magic and meaning of Mendel's miracle.

Nature reviews. Genetics·2022
Same author

MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface.

eLife·2021
Same author

Loss of sister kinetochore co-orientation and peri-centromeric cohesin protection after meiosis I depends on cleavage of centromeric REC8.

Developmental cell·2021
Same author

Organization of Chromosomal DNA by SMC Complexes.

Annual review of genetics·2019
Same author

Sister DNA Entrapment between Juxtaposed Smc Heads and Kleisin of the Cohesin Complex.

Molecular cell·2019
Same author

A folded conformation of MukBEF and cohesin.

Nature structural & molecular biology·2019
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
Same journal

Systematic discovery of pathogen effector functions across human pathogens and pathways.

Cell·2026
See all related articles

Related Experiment Video

Updated: May 4, 2026

Modeling Verbal Behavior Deficits with the Stimulus Control Ratio Equation, SCoRE
06:57

Modeling Verbal Behavior Deficits with the Stimulus Control Ratio Equation, SCoRE

Published on: May 14, 2019

11.0K

How do so few control so many?

Kim Nasmyth1

  • 1Research Institute of Molecular Pathology, Vienna, Austria.knasmyth@imp.univie.ac.at

Cell
|March 31, 2005
PubMed
Summary
This summary is machine-generated.

The anaphase-promoting complex/cyclosome (APC/C) controls cell division by regulating the destruction of securin, an inhibitor of separase. New research reveals how Mad2, a key inhibitor, is transferred to Cdc20 to prevent premature sister chromatid separation.

More Related Videos

Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface
11:54

Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface

Published on: May 8, 2021

4.2K
Experimental Investigation of the Hierarchical Control in DC Microgrids Using a Real-time Simulator
06:04

Experimental Investigation of the Hierarchical Control in DC Microgrids Using a Real-time Simulator

Published on: February 14, 2025

1.1K

Related Experiment Videos

Last Updated: May 4, 2026

Modeling Verbal Behavior Deficits with the Stimulus Control Ratio Equation, SCoRE
06:57

Modeling Verbal Behavior Deficits with the Stimulus Control Ratio Equation, SCoRE

Published on: May 14, 2019

11.0K
Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface
11:54

Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface

Published on: May 8, 2021

4.2K
Experimental Investigation of the Hierarchical Control in DC Microgrids Using a Real-time Simulator
06:04

Experimental Investigation of the Hierarchical Control in DC Microgrids Using a Real-time Simulator

Published on: February 14, 2025

1.1K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Sister chromatid separation is essential for accurate cell division, occurring at the metaphase-to-anaphase transition.
  • This process is tightly regulated by the anaphase-promoting complex or cyclosome (APC/C), which targets securin for destruction.
  • Securin inhibits separase, a protease that cleaves proteins holding sister chromatids together.

Purpose of the Study:

  • To elucidate the mechanism by which Mad2 inhibits Cdc20, thereby preventing premature sister chromatid separation.
  • To understand the role of Mad1 in the transfer of Mad2 to Cdc20 at kinetochores.

Main Methods:

  • The abstract does not specify the methods used.
  • Focuses on the molecular interactions and regulatory pathways involved in cell cycle control.

Main Results:

  • Mad2, sequestered by unattached kinetochores, inhibits Cdc20.
  • Mad1 facilitates the transfer of Mad2 to Cdc20.
  • This inhibition prevents the activation of separase and premature sister chromatid separation.

Conclusions:

  • The Mad1-Mad2 complex plays a crucial role in the spindle assembly checkpoint by inhibiting the APC/C.
  • Proper chromosome alignment is ensured by the timely inhibition and subsequent release of Cdc20.
  • Understanding this mechanism is vital for comprehending cell cycle regulation and aneuploidy.