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Related Experiment Videos

Wetting fibers with liposomes.

N Borghi1, K Alias, P-G de Gennes

  • 1Laboratoire PCC Institut Curie/CNRS UMR 168, 11, rue P. & M. Curie, 75005 Paris, France.

Journal of Colloid and Interface Science
|March 31, 2005
PubMed
Summary

Giant unilamellar vesicles (GUVs) form an onduloidal shape on glass microfibers, spreading via envelopment and precursor film emission. This process, faster than on flat surfaces, leads to pore formation and liquid leakage, enabling a novel fiber coating technique.

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Area of Science:

  • Biophysics
  • Materials Science
  • Surface Chemistry

Background:

  • Giant unilamellar vesicles (GUVs) are crucial model systems for cell membranes.
  • Understanding vesicle behavior on surfaces is key for applications like drug delivery and coatings.
  • Previous studies have not fully elucidated the spreading dynamics of GUVs on fibrous substrates.

Purpose of the Study:

  • To investigate the spreading mechanisms of giant unilamellar vesicles (GUVs) on glass microfibers.
  • To characterize the unique shape adopted by GUVs on fibers.
  • To explore the potential of this phenomenon for developing new fiber coating techniques.

Main Methods:

  • Deposition of GUVs onto glass microfiber substrates.
  • High-resolution microscopy to observe vesicle morphology and spreading dynamics.

Related Experiment Videos

  • Analysis of spreading mechanisms, including envelopment and precursor film formation.
  • Characterization of vesicle pore formation and liquid leakage.

    • Main Results:

    • GUVs adopt a classical "onduloidal" shape when deposited on glass microfibers.
    • Vesicle spreading occurs through simultaneous envelopment and precursor film emission.
    • The precursor film spreads significantly faster on microfibers compared to flat surfaces.
    • Fast spreading induces membrane tension, leading to transient pore opening and liquid leakage.
    • The spreading process is arrested by defects present on the microfiber surface.

    Conclusions:

    • The interaction of GUVs with microfibers involves distinct spreading mechanisms leading to unique morphologies.
    • The accelerated spreading and subsequent pore formation offer a novel pathway for fiber coating.
    • This research provides fundamental insights into fluid dynamics at the microscale and opens avenues for materials engineering.