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Soluble mediators of inflammation during tumor development
Stephen C Robinson1, Lisa M Coussens
1Cancer Research Institute, University of California, San Francisco, 94143, USA.
Advances in Cancer Research
|March 31, 2005
Summary
Tissue repair mechanisms normally resolve damage, but cancer involves dysregulated repair. Proinflammatory cytokines and chemokines are implicated in promoting carcinogenesis by altering tissue repair pathways.
Area of Science:
- Cellular biology
- Immunology
- Oncology
Background:
- Tissues rely on regulatory circuits to repair damage and maintain homeostasis.
- Cancer is a chronic disease characterized by dysregulated tissue repair processes.
Purpose of the Study:
- To explore the role of chemoattractant cytokines and chemokines in cancer development.
- To understand how inflammation and angiogenesis are regulated during carcinogenesis.
Main Methods:
- Review of clinical and experimental data.
- Analysis of chemoattractant cytokine and chemokine expression and activation in cancer.
Main Results:
- Proinflammatory cytokines and chemokines are key mediators of leukocyte recruitment.
- These molecules show altered expression and activation in chronically inflamed tissues.
- They are implicated as regulators of inflammation and angiogenesis in cancer.
Conclusions:
- Dysregulated tissue repair pathways contribute to chronic diseases like cancer.
- Proinflammatory cytokines and chemokines are significant potentiators of carcinogenesis.