Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

SL trans-splicing: easy come or easy go?

Kenneth E M Hastings¹

¹Montreal Neurological Institute and Department of Biology, McGill University, 3801 University St, Montreal, Quebec, Canada H3A 2B4. ken.hastings@mcgill.ca

Trends in Genetics : TIG

|March 31, 2005

Summary

Spliced-leader (SL) trans-splicing may be an ancient eukaryotic trait. Its presence in chordates offers a unique model to study the evolution of this RNA processing mechanism.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy.

Nature communications·2019

Same author

Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2015

Same author

A pipeline for the systematic identification of non-redundant full-ORF cDNAs for polymorphic and evolutionary divergent genomes: Application to the ascidian Ciona intestinalis.

Developmental biology·2015

Same author

Cross-validated methods for promoter/transcription start site mapping in SL trans-spliced genes, established using the Ciona intestinalis troponin I gene.

Nucleic acids research·2010

Same author

Pathogenic peptide deviations support a model of adaptive evolution of chordate cardiac performance by troponin mutations.

Physiological genomics·2010

Same author

High-throughput sequence analysis of Ciona intestinalis SL trans-spliced mRNAs: alternative expression modes and gene function correlates.

Genome research·2010

Area of Science:

Molecular Biology
Evolutionary Biology
Genomics

Background:

Spliced-leader (SL) trans-splicing is a unique RNA processing event.
Its evolutionary origin—whether ancestral or independent—remains debated.
Recent discoveries have expanded the known distribution of SL trans-splicing.

Purpose of the Study:

To investigate the evolutionary history of SL trans-splicing.
To explore the implications of SL trans-splicing in chordates.
To consider the relationship between SL trans-splicing, splice-signal syntax, and evolutionary genomics.

Main Methods:

Literature review and synthesis of recent findings.
Comparative analysis of SL trans-splicing across metazoan phyla.
Examination of evolutionary genomics data.

Main Results:

SL trans-splicing has been identified in new metazoan phyla, including chordates.
Chordates represent a phylum with both trans-splicing and non-trans-splicing groups.
This finding provides a focused system for studying SL trans-splicing evolution.

Conclusions:

The discovery in chordates refines the study of SL trans-splicing evolution.
Understanding SL trans-splicing dynamics is crucial for evolutionary genomics.
Further research can elucidate the interplay between splicing mechanisms and genome evolution.

Related Experiment Videos