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Updated: Aug 18, 2026

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
Genomic determinants of prognosis in colorectal cancer
Elisenda Vendrell1, Cristina Morales, Rosa-Ana Risques
1IDIBELL-Institut de Recerca Oncològica, Hospital Duran i Reynals, Granvia km 2,7, L'Hospitalet, Barcelona 08907, Spain.
Abstract:
Colorectal cancer progression is characterized by the sequential acquisition of multiple genetic aberrations. Insights into the biology of cancer cell and the development of novel methodologies have open a new frontier in the search of independent molecular factors to better predict outcome. Besides the generation of a large list of candidate markers, their applicability in routine clinical settings has been hindered by the heterogeneity of the disease. The analysis of cumulated genetic damage offers a more comprehensive measure of the cancer cell's genomic disruption and appears as a gauge of malignant potential. The prognostic application of different determinants of genomic damage is reviewed.
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