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Frequent overexpression of cyclin D2/cyclin-dependent kinase 4 in Wilms' tumor
Marine Faussillon1, Lucie Monnier, Claudine Junien
1INSERM U383, Hôpital Necker-Enfants Malades, Université René Descartes, 149-161 rue de Sèvres, 75743 Paris Cedex 15, France.
Abstract:
The expression status of the three cyclin D genes (CCND1, CCND2 and CCND3), the two cyclin D-dependent kinase genes (CDK4 and CDK6) and the p16(INK4a) gene was studied in a series of 47 Wilms' tumors, 16 normal mature kidneys and two fetal kidneys. We showed predominant overexpression of CCND2 and CDK4 compared to CCND1/D3 and CDK6 respectively. We found a specific correlation between relapse and CDK4 overexpression, but not CDK6 overexpression. We did not identify any methylation of the p16(INK4a) promoter. This suggests that dysregulation of CCND2 and CDK4 plays a specific role in WT tumorigenesis.
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