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Mild renal dysfunction is associated with electrocardiographic left ventricular hypertrophy

Tom D J Smilde1, Folkert W Asselbergs, Hans L Hillege

  • 1Department of Cardiology, Thoraxcenter, University Hospital Groningen, Hanzeplein 1, P.O. Box 30001, 9700 RB Gronigen, The Netherlands. t.d.j.smilde@thorax.azg.nl

American Journal of Hypertension
|March 31, 2005
PubMed

Insights

Mild renal dysfunction significantly increases the risk of left ventricular hypertrophy (LVH), a marker of cardiovascular disease. This study highlights the link between kidney health and heart structure in a large population.

Area of Science:

  • Cardiology
  • Nephrology
  • Public Health

Background:

  • Renal dysfunction and left ventricular hypertrophy (LVH) signify end-organ damage and are cardiovascular disease risk markers.
  • Previous studies suggest a link between renal dysfunction and LVH in specific populations like diabetics or hypertensives.
  • This cross-sectional study investigated the association between renal dysfunction and LVH in 8592 individuals.

Purpose of the Study:

  • To examine the relationship between renal dysfunction and left ventricular hypertrophy (LVH).
  • To determine if renal dysfunction is an independent predictor of LVH.
  • To assess the prevalence of LVH in individuals with and without renal dysfunction.

Main Methods:

  • Utilized standard 12-lead electrocardiograms to identify LVH using the Cornell voltage duration product.
  • Defined renal dysfunction as creatinine clearance <60 mL/min/1.73 m(2) or the presence of microalbuminuria (30 to 300 mg/24 h).
  • Employed multivariate regression analysis to assess independent associations.

Main Results:

  • Electrocardiographic LVH was detected in 5.3% of subjects, who were generally older with a higher cardiovascular risk profile.
  • LVH prevalence was significantly higher in subjects with renal dysfunction (8%) compared to those without (4%, P < .001).
  • Renal dysfunction independently predicted LVH (OR = 1.47, P = .009), with both reduced creatinine clearance (OR = 1.56, P = .044) and microalbuminuria (OR = 1.37, P = .024) showing independent associations.

Conclusions:

  • Mild renal dysfunction is associated with a substantially increased risk of electrocardiographic left ventricular hypertrophy.
  • The findings underscore the importance of assessing renal function in cardiovascular risk stratification.
  • Early detection and management of renal dysfunction may help mitigate the risk of LVH and associated cardiovascular complications.
Abstract

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