Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A unifying pathway for essential hypertension.

Richard J Johnson1, Bernardo Rodriguez-Iturbe, Duk-Hee Kang

  • 1Division of Nephrology, Hypertension and Transplantation, PO Box 100224, University of Florida, Gainesville, FL 32610, USA. johnsrj@medicine.ufl.edu

American Journal of Hypertension
|March 31, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interdialytic blood pressure is independent of weight gain and correlated with serum angiotensin II levels in adults.

Physiological reports·2026
Same author

Long-Term Exposure to Fine Particulate Matter and Kidney Function among Patients with Polycystic Kidney Disease.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

Association between estimated time with low glomerular filtration rate and access to transplant among youth with advanced chronic kidney disease.

Pediatric nephrology (Berlin, Germany)·2026
Same author

Bilateral Glomerulocystic Kidney Disease With Extensive Embryonal Hyperplasia in a Setting of <i>HNF1B</i> Mutation.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2026
Same author

Dosing trajectories of antihypertensive agents among preterm neonates: A retrospective, cross-sectional analysis.

PloS one·2025
Same author

The interplay of NAD+, hyperuricemia, and renal damage: A scientific review.

Pathology, research and practice·2025
Same journal

Hemodynamic Evolution of Heart Failure from Hypertension: Lower Stroke Volume Index and Higher Heart Rate.

American journal of hypertension·2026
Same journal

Opposite Seasonal Variation in Nighttime and Morning Blood Pressure: A Longitudinal Study of Patients with Hypertension.

American journal of hypertension·2026
Same journal

Screening for Postprandial Hypotension: The Importance of Home Blood Pressure Monitoring.

American journal of hypertension·2026
Same journal

Distinct Mediating Roles of Hypertension in Arterial Stiffness Mechanisms Associated with Cardiovascular Disease Risk: A Community-Based Cohort Study.

American journal of hypertension·2026
Same journal

Long-term systolic blood pressure time in target and risk of cardiovascular events in older adults: a secondary analysis of the ASPREE cohort.

American journal of hypertension·2026
Same journal

Estimated Pulse Wave Velocity Predicts Outcomes After Acute Ischemic Stroke: A Multinational Cohort Analysis.

American journal of hypertension·2026
See all related articles

Essential hypertension may develop in two phases, starting with renal vasoconstriction and progressing to salt-sensitive hypertension due to kidney disease. This new model integrates various hypertension hypotheses for potential prevention and treatment strategies.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Endocrinology

Background:

  • Essential hypertension is a complex condition with multifactorial origins.
  • Previous hypotheses often focused on isolated mechanisms, lacking a unifying framework.
  • The role of renal hemodynamics and inflammation in hypertension pathogenesis requires further elucidation.

Purpose of the Study:

  • To propose a two-phase hypothesis for the development of essential hypertension.
  • To integrate disparate etiological factors into a cohesive pathophysiological model.
  • To identify potential targets for preventing and treating hypertension.

Main Methods:

  • This study presents a theoretical hypothesis based on existing scientific literature.
  • The proposed model synthesizes concepts of sympathetic nervous system activity, renin-angiotensin system, hyperuricemia, and renal vascular changes.

Related Experiment Videos

  • It describes the transition from an early, renin-dependent phase to a later, volume-dependent phase of hypertension.

    • Main Results:

    • The hypothesis posits an initial phase characterized by renal vasoconstriction, salt resistance, and normal kidney structure.
    • Over time, preglomerular vascular disease (arteriolosclerosis) and tubulointerstitial inflammation develop.
    • This progression shifts hypertension to a salt-sensitive, volume-dependent, and renal-dependent state.

    Conclusions:

    • The two-phase model offers a unifying perspective on essential hypertension etiology.
    • It highlights the critical role of progressive renal vascular disease and inflammation.
    • This framework may guide the development of novel therapeutic and preventive strategies for hypertension.