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Genetic control of programmed cell death in Drosophila melanogaster

Peter Cashio1, Tom V Lee, Andreas Bergmann

  • 1The University of Texas, MD Anderson Cancer Center, Department of Biochemistry and Molecular Biology, The Genes and Development Graduate Program, Houston, TX 77030, USA.

Seminars in Cell & Developmental Biology
|March 31, 2005
PubMed

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Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...