Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Programmed cell death during amphibian metamorphosis.

Keisuke Nakajima1, Kenta Fujimoto, Yoshio Yaoita

  • 1Division of Embryology and Genetics, Institute for Amphibian Biology, Graduate School of Science, Hiroshima University, Higashihiroshima 739-8526, Japan.

Seminars in Cell & Developmental Biology
|March 31, 2005
PubMed
Summary

Amphibian metamorphosis involves programmed cell death, regulated by thyroid hormone signaling. This process drives organ remodeling, such as tail resorption, through cell suicide and extracellular matrix degradation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Delayed Subaponeurotic Fluid Collection: An Additional Differential Diagnosis of Scalp Swelling.

Pediatrics international : official journal of the Japan Pediatric Society·2026
Same author

Delivery Outcomes in the First 3 Years Following the Clinical Introduction of the Dinoprostone Vaginal Insert in Japan.

The journal of obstetrics and gynaecology research·2026
Same author

Effects of Thyroid Hormone Receptor α Gene Knockout on Hindlimb and Intestinal Development in Pre-Metamorphic Xenopus tropicalis Larvae.

Development, growth & differentiation·2026
Same author

Differentiation of focal liver lesions in contrast-enhanced ultrasound using a heuristic-guided hybrid machine-learning framework.

Journal of medical ultrasonics (2001)·2026
Same author

Stage-specific risks of mortality and renal outcomes in cardiovascular-kidney-metabolic syndrome: findings from a nationwide Japanese cohort.

Clinical and experimental nephrology·2025
Same author

Traumatic Atlantoaxial Rotatory Fixation in a Young Child.

Neurology·2025

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Endocrinology

Background:

  • Amphibian metamorphosis is a complex developmental process involving significant tissue remodeling.
  • Cell death is a critical and precisely regulated event during this transformation.
  • Thyroid hormones play a key role in orchestrating developmental changes.

Purpose of the Study:

  • To review the fundamental mechanisms of cell death during amphibian metamorphosis.
  • To highlight the role of thyroid hormone signaling in regulating cell death.
  • To focus on specific examples like tail resorption, intestinal, and skin remodeling.

Main Methods:

  • This review synthesizes existing research on amphibian metamorphosis.
  • It examines the molecular pathways governing programmed cell death.

Related Experiment Videos

  • Focus is placed on the interplay between cell-autonomous death and extracellular matrix degradation.

    • Main Results:

    • Programmed cell death is essential for organ remodeling during metamorphosis.
    • Thyroid hormone signaling triggers cell death via cell-autonomous mechanisms (suicide).
    • Extracellular matrix degradation, termed 'murder,' also contributes to tissue remodeling.

    Conclusions:

    • Thyroid hormones are central regulators of cell death during amphibian metamorphosis.
    • Metamorphosis involves both cellular self-destruction and matrix breakdown.
    • Understanding these mechanisms provides insights into developmental cell death.