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Updated: Aug 18, 2026

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
06:43

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 7, 2013

Aortic sclerosis: not an innocent murmur but a marker of increased cardiovascular risk

A K Nightingale1, J D Horowitz

  • 1Department of Cardiology, The Queen Elizabeth Hospital, The University of Adelaide, Adelaide, Australia. drangus@doctors.org.uk

Heart (British Cardiac Society)
|March 31, 2005
PubMed

Insights

Aortic sclerosis, detected by ejection systolic murmurs, indicates future aortic valve obstruction and cardiovascular event risk. It serves as a valuable tool for cardiovascular risk stratification.

Area of Science:

  • Cardiology
  • Valvular Heart Disease

Background:

  • Ejection systolic murmurs in the aortic region suggest aortic sclerosis or minor aortic valve disruption.
  • Aortic sclerosis is linked to future significant aortic valve obstruction.
  • It also serves as a marker for increased cardiovascular event risk.

Purpose of the Study:

  • To review evidence supporting aortic sclerosis in cardiovascular risk stratification.
  • To highlight the progression of aortic sclerosis to aortic stenosis as a focus for monitoring and intervention.

Main Methods:

  • Literature review of evidence on aortic sclerosis.
  • Analysis of its role in risk stratification and progression to stenosis.

Main Results:

  • Aortic sclerosis is a significant predictor of future aortic valve obstruction.
  • It is a valuable adjunctive tool for cardiovascular risk stratification.
  • Progression to hemodynamically significant aortic stenosis is a key clinical implication.

Conclusions:

  • Aortic sclerosis is crucial for identifying individuals at higher risk of cardiovascular events.
  • Monitoring the progression of aortic sclerosis to aortic stenosis is important for patient management and research.

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