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Updated: Aug 6, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Excess factor VIII: a common cause of hypercoagulability
1Department of Family Medicine, Stony Brook University, Stony Brook, NY, USA. rbobrow@notes.cc.sunysb.edu
Background:
Elevations of coagulation factor VIII have recently been described in significant numbers of patients with venous thromboembolism (VTE) previously thought to have had an "idiopathic" event. Three patients from a family practice are presented with recurrent VTE and increased factor VIII levels.
Method:
The case histories and results of laboratory tests were reviewed.
Results:
The 3 patients had no other clear coagulopathy. In 2 of the 3, the increase was confirmed with a second reading.
Conclusions:
Factor VIII assay should be considered in the work-up of idiopathic, recurrent VTE. Long-term anticoagulation may be appropriate in this setting.
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