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Related Experiment Videos

Does prolonged pneumoperitoneum affect oxidative stress compared with open surgical procedures?

Ruben Urena1, Freddy Mendez, Gilberto Ruiz-Deya

  • 1Department of Urology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA.

Journal of Endourology
|March 31, 2005
PubMed
Summary

Both laparoscopic and open urologic surgeries increase oxidative stress, measured by urinary 8-iso-prostaglandin F2a. Levels return to near baseline within 18 hours, with no significant difference between surgical types.

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Area of Science:

  • Urology
  • Surgical Innovation
  • Oxidative Stress Research

Background:

  • Laparoscopic surgery is increasingly used for complex urologic procedures.
  • Pneumoperitoneum in laparoscopy causes physiological changes, potentially affecting kidney redox status.
  • The impact of prolonged pneumoperitoneum on oxidative stress compared to open surgery is not well understood.

Purpose of the Study:

  • To compare the levels of oxidative stress between patients undergoing urologic laparoscopic surgery and open surgery.
  • To investigate the association between pneumoperitoneum and oxidative stress markers.

Main Methods:

  • Urine samples collected from 10 laparoscopic and 10 open surgery patients preoperatively and at 6, 18 hours postoperatively.
  • Measured urinary concentrations of 8-iso-prostaglandin F2a, a marker of oxidative stress.

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  • Analyzed results in relation to surgical type and clinical factors.

    • Main Results:

    • Urinary isoprostane levels increased immediately post-surgery in both groups, peaking at 189.0% (laparoscopic) and 141.1% (open) of preoperative values.
    • Isoprostane levels decreased by 6 hours and returned near baseline by 18 hours post-surgery in both groups.
    • No significant differences in oxidative stress markers were found between laparoscopic and open surgery groups at any time point.

    Conclusions:

    • Both laparoscopic and open urologic surgeries induce a temporary increase in oxidative stress.
    • Urinary 8-iso-prostaglandin F2a levels normalize within 18 hours postoperatively, regardless of surgical approach.
    • Prolonged operative time in laparoscopic surgery did not appear to influence oxidative stress levels.