Related Experiment Videos
The comparison of overnight lens modalities (COLM) study
Eric R Ritchey1, Joseph T Barr, G Lynn Mitchell
1University of Missouri-Saint Louis, College of Optometry, Saint Louis, MO, USA. eritchey@optometry.osu.edu
Eye & Contact Lens
|March 31, 2005
Summary
This study found no significant difference in visual acuity between two types of overnight contact lenses. However, the National Eye Institute Refractive Error Quality of Life Instrument showed a difference in dependence on correction for CRT lenses.
Area of Science:
- Ophthalmology
- Optometry
- Biomedical Engineering
Background:
- Continuous wear contact lenses offer an alternative to corrective eyewear.
- Silicone hydrogel lenses are designed for extended wear.
- Assessing visual acuity and quality of life is crucial for contact lens evaluation.
Purpose of the Study:
- To determine the sample size for a clinical trial comparing two overnight contact lens modalities.
- To compare the efficacy and quality of life outcomes between Paragon CRT and CIBA Vision Focus NIGHT and DAY lenses.
Main Methods:
- A pilot study involving 20 subjects, with 18 completing the 3-month trial.
- Assessment of visual acuity and refractive quality of life using standardized instruments.
- Nonparametric statistical analyses, including Wilcoxon tests, to compare treatment groups.
Main Results:
- No significant differences in visual acuity or most quality of life measures between lens types.
- A statistically significant difference was found in the 'dependence-on-correction' scale of the NEI RQL-42 (P=0.0032).
- A sample size of 126 subjects per group is recommended for future trials.
Conclusions:
- The NEI RQL-42 may detect subtle differences in quality of life related to contact lens wear.
- Both Paragon CRT and Focus NIGHT and DAY lenses provide comparable visual acuity.
- Further research with a larger sample size is needed to confirm these findings.